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KMID : 0389420170250010001
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Korean Journal of Stress Research
2017 Volume.25 No. 1 p.1 ~ p.7
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Current Therapeutic Approaches in Spinal Cord Injury : Pharmacological, Rehabilitation, Cell-based, and Psychological Intervention
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Lim Woo-Taek
Choi Bong-Sam
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Abstract
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The purpose of this review is to discuss current therapeutic interventions and their limitations for the optimal treatment outcomes of individuals with spinal cord injury (SCI). SCI leads to neurologic deficits and subsequent severe muscle atrophy. In clinics, despite the controversy, pharmacological therapy using methylprednisolone has widely been accepted to reduce additional neurologic deficits caused by a secondary injury such as oxidative stress and lipid peroxidation. Moreover, it facilitates the recovery process. Since the loss of locomotor function may reduce the quality of life for individuals with SCI, many pre-clinical and clinical studies have focused on the recovery of locomotor function. Various forms of locomotor training such as treadmill training, cycle training, and robotic-assisted training are currently available for individuals with SCI. Additionally the cell-based interventions have been receiving much attention as one of potential therapeutic interventions which required further clarifications due to the issues of safety. The physical impairment associated with spinal cord injury may cause an adverse effect on mental health. It is now recommended that combined physical and psychological interventions should be considered to maximize the efficacy of therapeutic interventions.
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KEYWORD
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Locomotor training, Post-traumatic stress disorder, Spinal cord injury, Stem cell, Steroid
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